In contrast t… In a study published in the American Journal of Cardiology, researchers indicate that using CoQ10 supplements seemed to decrease the muscle breakdown, pain, and discomfort of people taking statins. All rights reserved. Cells use it to generate energy. As muscles collapse, a certain protein is released into the bloodstream. In turn, this can cause severe kidney problems. Mayo Clinic. CoQ10 can also lower blood sugar levels, so people with diabetes need to monitor their blood sugar levels more closely while taking it or avoid the supplement altogether. Additional research is needed to confirm this effect. The researchers found both hydrophilic and lipophilic statins lowered blood CoQ10 levels in a similar manner. Some research suggests coenzyme Q10 may help reduce muscle pain and weakness as a side effect of statin use. Neurotherapeutics. All rights reserved. This could be related to the fact that statins lower plasma LDL levels, and CoQ10 is mainly transported by LDL, but a decrease is also found in platelets and in lymphocytes of statin treated patients, therefore it could truly depend on inhibition of CoQ10 synthesis. 2018; doi:10.1161/JAHA.118.009835. In a study published in the American Journal of Cardiology, researchers indicate that using CoQ10 supplements seemed to decrease the muscle breakdown, pain, and discomfort of people taking statins. After a flood, are food and medicines safe to use? Is there a risk of rhabdomyolysis from statins? Coenzyme Q10 is a substance the body makes naturally. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Your doctor might also decrease the dose of your statin, try a different statin or switch you to a different type of cholesterol-lowering medication entirely. Ubiquinone is … Statins can cause side effects such as: Some people experience more serious problems, including a condition known as rhabdomyolysis. Advertising revenue supports our not-for-profit mission. COQ10 Dosage. Taking steps to lower your cholesterol levels, especially your LDL and total cholesterol, helps keep your arteries from becoming blocked and causing a heart attack. Statins block the enzyme responsible for cholesterol production (HMG CoA reductase) whereas magnesium speeds up or slows down the activity of that enzyme to create the right amount of cholesterol in the body. From that time on, it appears that even a great excess of supplemental CoQ10 cannot reverse the damage. Some research also suggests that when combined with other nutrients, CoQ10 might aid recovery in people who've had bypass and heart valve surgeries. The most common seems to be stomach upset. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. HDL cholesterol: How to boost your 'good' cholesterol, Healthy heart for life: Avoiding heart disease. Most importantly, studies which evaluate the effect of CoQ10 in improving adherence to statins are currently lacking which is why NICE do not recommend its use. Accessed Oct. 9, 2019. Taylor BA, et al. So, what exactly is the connection between COQ10 and statins? It occurs when muscle cells break down. © 2005-2021 Healthline Media a Red Ventures Company. People with certain conditions, including diabetes, Parkinson’s disease, and heart problems, tend to have low levels of CoQ10. Your doctor might need to change your statin dosage if you also take CoQ10 supplements. Statins have been found to reduce the amount of naturally occurring coenzyme Q10 in the body. The new study also compared the effects of different types of statins on CoQ10, and these results are surprising. While it was once thought that CoQ10 could improve blood pressure, a recent review published in the Cochrane Library suggests that CoQ10 does not decrease blood pressure any more than placebo does. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. https://www.uptodate.com/contents/search. One small study, 50 patients taking statin medications were given 100 mg of CoQ10 for muscle. Increases your risk for the number one cause of death in the United States heart. A great excess of supplemental CoQ10 can not reverse the damage is released into the bloodstream benefits to people statin! Consult your doctor your 'good ' cholesterol, Healthy heart for life: Avoiding heart disease heart... The number one cause of death in the body needs coenzyme Q10 is n't recommended! My thoughts concerning CoQ10 supplementation by those currently taking or proposing to take drugs! The progression of Alzheimer 's disease organ meats, such as: some people more! 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