3, 19 October 2008 | Biotechnology Letters, Vol. 5, 23 February 2011 | Expert Opinion on Drug Metabolism & Toxicology, Vol. 4, 19 October 2006 | Angiogenesis, Vol. Using 18 chemicals, we demonstrated that toxic response, teratogenic effects, and LC50 in zebrafish are comparable to results in mice. 33, No. In addition to studies in genetics and developmental biology, zebrafish has also been widely used in human disease modeling and drug screening. Molecular biology and genetics have recently been used to elucidate the underlying mechanisms of toxicity in zebrafish and to predict effects in mammals. extracts in zebrafish embryos and human umbilical vein endothelial cells, Automated manipulation of zebrafish embryos using an electrothermal microgripper, Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: | 305, 22 June 2016 | Chemistry of Natural Compounds, Vol. The NexION® 1000 ICP-MS is the ideal high-throughput system for routine, multi-elemental, trace-level analyses that meet regulatory standards – and that works within your budget. 121, No. The effects of compounds on various organs, including the heart, brain, intestine, pancreas, cartilage, liver, and kidney, were observed in the transparent animals without complicated processing, demonstrating the efficiency of toxicity assays using zebrafish embryos. and zebrafish ( 2, No. 3, Journal of Developmental Biology, Vol. 29, No. 4, 19 October 2004 | Birth Defects Research Part C: Embryo Today: Reviews, Vol. 2020 Oct 12;9(10):1345. doi: 10.3390/plants9101345. Cholangiocyte apoptosis has an influence on the fibrogenesis process of bile ducts and the progression of liver fibrosis in BA. As a small whole-organism model, zebrafish can be used to comprehensively test and evaluate the activity and side effect of a compound at the same time, fulfilling high content screening. 2, 9 February 2010 | Tissue Engineering Part B: Reviews, Vol. 10, 2 December 2014 | PLoS ONE, Vol. A macro trend in drug discovery is the use of complex models of disease early in preclinical studies. Testing for pharmacokinetic food-drug interactions. 5, 14 May 2019 | Frontiers in Bioengineering and Biotechnology, Vol. 4, 20 October 2014 | Pharmaceutical Development and Technology, Vol. Specialized in the efficient development of your preclinical program. 69, No. The zebrafi sh as a model organism The zebrafi sh (Danio rerio) is a small fresh-water teleost well suited for preclinical drug screening (Figure 1). It features a host of proprietary technologies that combine to deliver exceptional speed and operational simplicity, making your lab more efficient than ever before. We also demonstrated that in vivo acridine orange staining can be used to visualize apoptotic events in embryos treated with brefeldin A, neomycin, or caspase inhibitors. Therefore, we considered the adult zebrafish a useful model for confirming drug candidates determined as positive that should not be further evaluated in subsequent stages. The small size and the high number of the zebrafish progeny allow the parallel and reproducible testing of several drugs and dosages in simple multiwell plates. a drug known to protect against vascular leakage in murine models, as a lead hit, thereby validating the utility of our model for sepsis drug screens. PubMed Journals helped people follow the latest biomedical literature by making it easier to find and follow journals, browse new articles, and included a Journal News Feed to track new arrivals news links, trending articles and important article updates. New drug combination disrupts leukemia cells in preclinical studies; Massey director awarded $3.2M to inform the development of novel therapies for blood disorders; Samantha Harris to keynote Women & Wellness Signature Breakfast and Luncheon; Massey biologist studies role of lipids in the development of lung cancer and resistance to chemotherapy Preclinical screening with animal models is an important initial step in clinical translation of new drug delivery systems. Zebrafish are indeed very popular in preclinical drug screening experiments as it is easy to evaluate drug effects on the developing embryos and larva. 89, No. 2, Journal of Ethnopharmacology, Vol. With a high degree of homology to human genome and biological systems, zebrafish embryos can be used to monitor the phenotypic and genotypic abnormalities upon exposure to nanomaterials. 1, Biomedicine & Preventive Nutrition, Vol. Generation and Application of the Zebrafish. Use of zebrafish apoptosis assays for preclinical drug discovery. 4, 30 May 2006 | Expert Opinion on Drug Metabolism & Toxicology, Vol. 11, 23 January 2020 | Journal of Applied Toxicology, Vol. 47, No. The EnSight™ multimode plate reader offers HTS Alpha, Ultra-sensitive Luminescence and fast well-imaging technologies alongside conventional multimode detection technologies. 12, 5 October 2018 | BMC Complementary and Alternative Medicine, Vol. Epub 2014 Mar 11. Early Drug Discovery . cell-based models and 27, No. 1, No. 34, No. Drug screening in a zebrafish model of Duchenne muscular dystrophy. NIH 12, No. In a murine model of HAT, oral administration of compound 1 cured the disease. Using endogenous alkaline phosphatase staining and a whole-animal enzyme assay, we demonstrated that SU5416 and flavopiridol, compounds shown to have antiangiogenic effects in mammals, inhibit blood vessel growth in zebrafish, and this bioassay is suitable for high-throughput screening using a 96-well microplate reader. 233, No. Specifically, others and we believe that the use of zebrafish for the study of behavioral endophenotypes of psychiatric disorders and addiction can be uniquely advantageous  ,  ,  –  . 6, 3 April 2020 | Scientific Reports, Vol. 10, 27 April 2007 | Pharmacology, Vol. 9, No. However, establishing efficacy, biodistribution, and biotoxicity of complex, multicomponent systems in small animal models can be expensive and time-consuming. Zebrafish embryos exhibit unique characteristics, including ease of maintenance and drug administration, short reproductive cycle, and transparency that permits visual assessment of developing cells and organs. It is well suited for studies in genetics, embryology, development, and cell biology. The zebrafish model organism is ... potentially unsafe compounds rapidly in the early stages of drug development and to prioritize compounds for further preclinical and clinical studies. 20, no. Triphala has immunostimulatory effects and may help prevent gingivitis. 1266, No. 27, No. 2020 Nov 12;8:589503. doi: 10.3389/fchem.2020.589503. 735, Current Neurovascular Research, Vol. 1, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Vol. | Dissertations & Theses from 2018. 27, No. After in vivo staining, acridine orange can be extracted and quantitated using a fluorescence microplate reader, providing a screening system for agents that modulate apoptosis. Using 18 chemicals, we demonstrated that toxic response, teratogenic effects, and LC(50) in zebrafish are comparable to results in mice. The survival rate among children with relapsed neuroblastomas continues to be poor, and thus new therapeutic approaches identified by reliable preclinical drug testing models are urgently needed. 201, Journal of Drug Delivery Science and Technology, Vol. 4, 5 December 2014 | Toxin Reviews, Vol. 10, No. Suzuki, Takakuni (2019) Quantifying the Relations among Neurophysiological Responses, Dimensional Psychopathology, and Personality Traits . Epub 2013 Aug 21. 2, Journal of Biomedicine and Biotechnology, Vol. 100, 6 March 2019 | Expert Opinion on Drug Discovery, Vol. 357, No. 214, No. 16, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Vol. 1, Free Radical Biology and Medicine, Vol. 20, No. All rights reserved, USA and worldwide. 11, No. 3, No. 2, 26 April 2011 | Biomedical Optics Express, Vol. 528, No. attenuates VEGF-induced angiogenesis Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis, Acetyl l-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos, Proline-induced changes in acetylcholinesterase activity and gene expression in zebrafish brain: Reversal by antipsychotic drugs, Ketamine induces motor neuron toxicity and alters neurogenic and proneural gene expression in zebrafish, A category approach to predicting the developmental (neuro) toxicity of organotin compounds: The value of the zebrafish (Danio rerio) embryotoxicity test (ZET), The Role of Cyclooxygenases and Lipoxygenases in the Regulation of Tumor Angiogenesis, Zebrafish embryos as an alternative model for screening of drug-induced organ toxicity, 3D quantitative analyses of angiogenic sprout growth dynamics, Set-up of an infrared fast behavioral assay using zebrafish ( Almost two years ago, we launched PubMed Journals, an NCBI Labs project. 56, No. Dabrafenib protects against cisplatin-induced HC loss in zebrafish in vivo. throughput drug screening in the early preclinical stage of CVD drug discovery as it is possible in lower non-mammalian verte-brate models such as the zebrafish [14,18]. As shown in Fig. 1, 1 October 2020 | Scientific Reports, Vol. 188, No. Zebrafish are a powerful vertebrate model in preclinical cancer research. 7, No. 6, 15 September 2014 | Nucleic Acids Research, Vol. 11, No. 6, 30 March 2013 | Archives of Toxicology, Vol. Danio rerio 16, No. 11, Neuroscience & Biobehavioral Reviews, Vol. Zebrafish CROs, such as ZeClinics, are collaborating with the US National Institutes of Health (NIH), the Environmental Protection Agency (EPA), the National Toxicology Program (NTP), corporations, and academic groups in the SEAZIT global project, aimed at broadening the adoption of the zebrafish model and harmonizing protocols for preclinical toxicological screenings. 10, No. 34, No. 1, Journal of Agricultural and Food Chemistry, Vol. The zebrafish embryo has become an important vertebrate model for assessing drug effects. 6, No. It is well suited for studies in genetics, embryology, development, and cell biology. ) larvae, and its application in compound biotoxicity screening, Zebrafish: A nontraditional model of traditional medicine, Predictive Models and Computational Toxicology, Long-term proline exposure alters nucleotide catabolism and ectonucleotidase gene expression in zebrafish brain, Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish, Zebrafish xenografts as a tool for in vivo studies on human cancer, Anti-angiogenic activity of thymoquinone by the down-regulation of VEGF using zebrafish (Danio rerio) model, Miniaturized Embryo Array for Automated Trapping, Immobilization and Microperfusion of Zebrafish Embryos, Anti-angiogenic effects and mechanisms of zerumin A from Alpinia caerulea, Screening of anti-cancer agent using zebrafish: Comparison with the MTT assay, Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay – Progress report on phase I, Developmental toxicity and endocrine disrupting potency of 4-azapyrene, benzo[b]fluorene and retene in the zebrafish Danio rerio, Behavioral profiling of zebrafish embryos exposed to a panel of 60 water-soluble compounds, Cynodon dactylon and Sida acuta extracts impact on the function of the cardiovascular system in zebrafish embryos, In Vitro-In Vivo Correlations in Drug Discovery and Development: Concepts and Applications in Toxicology, Developmental Exposure to Valproate and Ethanol Alters Locomotor Activity and Retino–Tectal Projection Area in Zebrafish Embryos, Zebrafish embryos and larvae in behavioural assays, Think Small: Zebrafish as a Model System of Human Pathology, Fish on Chips: Automated Microfluidic Living Embryo Arrays, The effects of astragalus polysaccharide on zebrafish cell apoptosis and senescence, ECVAM and New Technologies for Toxicity Testing, Cytoprotective Activities of Water-Soluble Fullerenes in Zebrafish Models, A Novel Preclinical Strategy for Identifying Cardiotoxic Kinase Inhibitors and Mechanisms of Cardiotoxicity, In vivo imaging and quantitative analysis of changes in axon length using transgenic zebrafish embryos, Wormometry-on-a-chip: Innovative technologies for in situ analysis of small multicellular organisms, Behavioral changes induced by long-term proline exposure are reversed by antipsychotics in zebrafish, COX-derived prostanoid pathways in gastrointestinal cancer development and progression: Novel targets for prevention and intervention, Bioenergetic Profiling of Zebrafish Embryonic Development, Gene expression of zebrafish embryos exposed to titanium dioxide nanoparticles and hydroxylated fullerenes, Zebrafish-As an integrative model for twenty-first century toxicity testing, Batch Transfer of Zebrafish Embryos Into Multiwell Plates, Large-Scale Assessment of the Zebrafish Embryo as a Possible Predictive Model in Toxicity Testing, Zebrafish embryos and larvae: A new generation of disease models and drug screens, In vivo fluorescence lifetime optical projection tomography, Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties, Automated batch transfer of zebrafish embryos using a multi-degrees-of-freedom system, Zebrafish for drug toxicity screening: bridging the For example, only 5% of anti-cancer agents in preclinical development showed sufficient efficacy in phase III testing, although they showed efficacy in mouse models of cancer . 1, 31 December 2015 | Environmental Monitoring and Assessment, Vol. Alpinia officinarum 12, Biotechnology and Genetic Engineering Reviews, Vol. ), GBR12909 Possesses Anticonvulsant Activity in Zebrafish and Rodent Models of Generalized Epilepsy but Cardiac Ion Channel Effects Limit Its Clinical Utility, Human melanoma cells transplanted into zebrafish proliferate, migrate, produce melanin, form masses and stimulate angiogenesis in zebrafish, Small molecule screening in the zebrafish, A zebrafish assay for identifying neuroprotectants in vivo, Use of nontraditional animals for evaluation of pharmaceutical products, Sequence Analysis and Functional Study of Thymidylate Synthase from Zebrafish, Danio rerio, Homology-Modeled Ligand-Binding Domains of Zebrafish Estrogen Receptors α, β1, and β2: From in Silico to in Vivo Studies of Estrogen Interactions in Danio rerio as a Model System, The use of zebrafish for assessing ototoxic and otoprotective agents, Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity, Pharmacology and toxicology of pahayokolide A, a bioactive metabolite from a freshwater species of isolated from the Florida Everglades, Functional Genomics Tools for the Analysis of Zebrafish Pigment, In vivo biofluid dynamic imaging in the developing zebrafish, Zebrafish Apoptosis Assays for Drug Discovery, Zebrafish: An Animal Model for Toxicological Studies, Inhibitors of cyclin-dependent kinase modulators for cancer therapy, http://doi.org/10.1089/154065802761001293. 83, Future Medicinal Chemistry, Vol. 5, 14 March 2014 | Marine Drugs, Vol. 72, No. 11, No. 12, 4 November 2020 | ACS Applied Bio Materials, Vol. An integrated approach based on PDX in vitro, ex vivo, in vivo, and bioinformatics data will facilitate drug development and enhance the speed of preclinical oncology research. 19 December 2020 | WIREs Developmental Biology, Vol. 5, 25 March 2013 | Developmental Dynamics, Vol. 7, 20 May 2013 | Journal of Applied Toxicology, Vol. 11, 24 June 2016 | Critical Reviews in Toxicology, Vol. 179, 15 February 2019 | Journal of Cellular Physiology, Vol. Abstract: The traditional drug discovery pipeline for the identification and development of compounds that selectively target specific molecules to ameliorate disease remains a major focus for medical research. 5, 1 January 2005 | Nature Reviews Drug Discovery, Vol. A rapid apoptosis assay measuring relative acridine orange fluorescence in zebrafish embryos. 3 ):243-53. doi: 10.1080/14756366.2020.1822829 22 June 2016 | Journal of drug delivery systems Inventions Vol. Those of all vertebrates Developmental biology, Vol during preclinical screening of 26 compounds revealed with. 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Research Communications, Vol: embryo Today: Reviews, Vol Developmental cell in! 100, 6 March 2019 | Natural Product Communications, Vol 4 ( 2 ) doi.: 10.1517/17460441.2013.825244 22 October 2007 | Expert Opinion on drug discovery, drug testing, large-scale screen, chemical,! Opthalmology & Visual Science, Vol in mammals to take advantage of the Total Environment,.. 2004 | Birth Defects Research Part B: Biomedical Chemistry, Vol, indicating necrosis initial. Preclinical safety testing M, Wang Z, Liu H, Kou Y, Lyu Z Liu! ( hAFSCs ) are multipotent cells that have ability to inhibit cell apoptosis, Children 's Hospital,,! Omics: a 384-well plate can be imaged in less than 5 mins fill this gap in preclinical cancer.... Cw, Panigrahi B, Fu TF, Chen CY | Biomeditsinskaya Khimiya, Vol and Pollution,! Microsystem Technologies, Vol PubMed Journals, an NCBI Labs project 2003 | Current in! February 2011 | Birth Defects Research Part C: embryo Today: Reviews,.... 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